Immune Enhancement of Clam Peptides on Immunosuppressed Mice Induced by Hydrocortisone

Clam peptides, marine-derived biological have been broadly investigated and applied as health foods, among which immunomodulation is one of their activities that cannot be ignored in vivo. In this study, we concentrated on exploring the effects Ruditapes philippinarum peptides (RPPs) balance intestinal microbiota hydrocortisone (HC)-induced immunosuppressed mice. The results revealed RPPs could increase thymus spleen indices number white blood cells, promote secretion level cytokines (IL-2, IL-6, TNF-α, INF-γ), repair morphology thymus, enhance proliferation T-lymphocyte subsets Moreover, improved abundance beneficial bacteria preserved ecological equilibrium gut microbiota. conclusion, significant immunomodulatory mice may developed immunomodulators or immune adjuvants functional foods drugs; they are also to utilization high value marine shellfish.